Download Mendeleyhuman citrate synthase complexed with oxaloacetate and coenzyme A
Yang, L.Y., Fang, Y.J.To be published.
8ZVW | pdb_00008zvw
human citrate synthase complexed with oxaloacetate and coenzyme A
- PDB DOI: https://doi.org/10.2210/pdb8ZVW/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2024-06-12 Released: 2025-06-18
- Funding Organization(s): National Natural Science Foundation of China (NSFC)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.82 Å
- R-Value Free: 0.298 (Depositor), 0.304 (DCC)
- R-Value Work: 0.223 (Depositor), 0.234 (DCC)
- R-Value Observed: 0.226 (Depositor)
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Citrate synthase, mitochondrial | 434 | Homo sapiens | Mutation(s): 0 Gene Names: CS EC: 2.3.3.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for O75390 (Homo sapiens) Explore O75390 Go to UniProtKB: O75390 | |||||
PHAROS: O75390 GTEx: ENSG00000062485 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | O75390 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| COA Query on COA | C [auth A] | COENZYME A C21 H36 N7 O16 P3 S RGJOEKWQDUBAIZ-IBOSZNHHSA-N |  | ||
| OAA Query on OAA | B [auth A] | OXALOACETATE ION C4 H3 O5 KHPXUQMNIQBQEV-UHFFFAOYSA-M |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.82 Å
- R-Value Free: 0.298 (Depositor), 0.304 (DCC)
- R-Value Work: 0.223 (Depositor), 0.234 (DCC)
- R-Value Observed: 0.226 (Depositor)
Space Group: P 43 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 57.37 | α = 90 |
| b = 57.37 | β = 90 |
| c = 250.67 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| xia2 | data reduction |
| xia2 | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-06-18 Deposition Author(s): Yang, L.Y., Fang, Y.J.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Natural Science Foundation of China (NSFC) | China | -- |
Revision History (Full details and data files)
- Version 1.0: 2025-06-18
Type: Initial release
