Download MendeleyStucrure of human Glutamate oxaloacetate transaminase 1 GOT1 mutant - P15R
Yang, X.W., Cao, Z., Zang, L., Wang, N.To be published.
8Z0E | pdb_00008z0e
Structure of human Glutamate oxaloacetate transaminase 1 (GOT1) mutant - P15R
- PDB DOI: https://doi.org/10.2210/pdb8Z0E/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2024-04-09 Released: 2025-04-16
- Funding Organization(s): National Natural Science Foundation of China (NSFC)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.82 Å
- R-Value Free: 0.211 (Depositor), 0.211 (DCC)
- R-Value Work: 0.168 (Depositor), 0.170 (DCC)
- R-Value Observed: 0.170 (Depositor)
Starting Model: in silico
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This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Aspartate aminotransferase, cytoplasmic | 413 | Homo sapiens | Mutation(s): 1 Gene Names: GOT1 EC: 2.6.1.1 (PDB Primary Data), 2.6.1.3 (PDB Primary Data) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P17174 (Homo sapiens) Explore P17174 Go to UniProtKB: P17174 | |||||
PHAROS: P17174 GTEx: ENSG00000120053 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P17174 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PLP (Subject of Investigation/LOI) Query on PLP | C [auth A], D [auth B] | PYRIDOXAL-5'-PHOSPHATE C8 H10 N O6 P NGVDGCNFYWLIFO-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.82 Å
- R-Value Free: 0.211 (Depositor), 0.211 (DCC)
- R-Value Work: 0.168 (Depositor), 0.170 (DCC)
- R-Value Observed: 0.170 (Depositor)
Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 89.952 | α = 90 |
| b = 97.072 | β = 90 |
| c = 97.427 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| DIALS | data reduction |
| HKL-3000 | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-04-16 Deposition Author(s): Yang, X.W., Cao, Z., Zang, L., Wang, N.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Natural Science Foundation of China (NSFC) | China | -- |
Revision History (Full details and data files)
- Version 1.0: 2025-04-16
Type: Initial release
