AF_AFQ9BT56F1

Computed structure model of Spexin

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Spexin	molecular transducer activity binding molecular function activator activity signaling receptor binding signaling receptor activity neuropeptide activity signaling receptor activator activity hormone activity protein binding molecular function regulator activity neuropeptide hormone activity signaling receptor regulator activity receptor ligand activity	response to nutrient levels regulation of response to nutrient levels regulation of biological process negative regulation of response to food response to stimulus negative regulation of response to nutrient levels negative regulation of response to stimulus biological regulation negative regulation of biological process negative regulation of appetite regulation of response to food regulation of response to stimulus response to food response to chemical response to nutrient levels regulation of response to nutrient levels regulation of biological process negative regulation of response to food response to stimulus negative regulation of response to nutrient levels negative regulation of response to stimulus biological regulation negative regulation of biological process negative regulation of appetite regulation of response to food regulation of response to stimulus response to food response to chemical regulation of biological quality regulation of appetite regulation of localization multicellular organismal process system process renal sodium excretion inorganic ion homeostasis regulation of renal system process transport homeostatic process regulation of system process negative regulation of transport localization negative regulation of secretion monoatomic ion homeostasis negative regulation of renal sodium excretion regulation of multicellular organismal process monoatomic cation homeostasis excretion renal system process sodium ion homeostasis regulation of transport secretion renal tubular secretion establishment of localization regulation of secretion regulation of renal sodium excretion chemical homeostasis negative regulation of multicellular organismal process regulation of excretion import into cell organic anion transport carboxylic acid transport lipid localization lipid transport organic acid transport monocarboxylic acid transport fatty acid transport lipid import into cell macromolecule localization long-chain fatty acid import into cell long-chain fatty acid transport nervous system process sensory perception of pain regulation of nervous system process sensory perception regulation of sensory perception regulation of sensory perception of pain heart process negative regulation of heart rate regulation of heart contraction negative regulation of blood circulation negative regulation of heart contraction circulatory system process regulation of blood circulation heart contraction blood circulation regulation of heart rate positive regulation of systemic arterial blood pressure regulation of systemic arterial blood pressure regulation of blood pressure positive regulation of blood pressure gastro-intestinal system smooth muscle contraction positive regulation of smooth muscle contraction positive regulation of biological process muscle contraction muscle system process regulation of muscle system process positive regulation of gastro-intestinal system smooth muscle contraction regulation of gastro-intestinal system smooth muscle contraction smooth muscle contraction regulation of smooth muscle contraction regulation of muscle contraction positive regulation of muscle contraction positive regulation of multicellular organismal process	membrane-bounded organelle intracellular anatomical structure dense core granule intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle membrane-bounded organelle intracellular anatomical structure dense core granule intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle transport vesicle extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR028126	Spexin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9BT56	osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma psoriasis atopic eczema Duchenne muscular dystrophy exocrine pancreatic carcinoma glioblastoma juvenile dermatomyositis malignant glioma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer subependymal giant cell astrocytoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma psoriasis atopic eczema Duchenne muscular dystrophy exocrine pancreatic carcinoma glioblastoma juvenile dermatomyositis malignant glioma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pituitary cancer subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor ductal breast carcinoma in situ gastric cancer hepatocellular carcinoma large cell medulloblastoma malignant mesothelioma oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor breast carcinoma Emery-Dreifuss muscular dystrophy gastric carcinoma invasive ductal breast carcinoma malignant ependymoma malignant pancreatic neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.