AF_AFQ5SZK8F5

Computed structure model of FRAS1-related extracellular matrix protein 2

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	FRAS1-related extracellular matrix protein 2	cation binding ion binding binding metal ion binding small molecule binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular process cell communication tissue morphogenesis anatomical structure morphogenesis epithelium development morphogenesis of an epithelium developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular process cell communication tissue morphogenesis anatomical structure morphogenesis epithelium development morphogenesis of an epithelium tissue development cell adhesion ear development sensory organ development inner ear development eye development visual system development sensory system development kidney development renal system development limb development appendage development embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis embryo development appendage morphogenesis embryonic digit morphogenesis limb morphogenesis	basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR045658	FRAS1-related extracellular matrix protein, N-terminal domain	Domain
A	IPR039005	CSPG repeat	Repeat
A	IPR003644	Na-Ca exchanger/integrin-beta4	Domain
A	IPR051561	FRAS1-related extracellular matrix	Family
A	IPR038081	CalX-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q5SZK8	Fraser syndrome congenital anomaly of kidney and urinary tract Fraser syndrome 2 medulloblastoma primitive neuroectodermal tumor amyotrophic lateral sclerosis breast cancer glioblastoma interstitial cystitis malignant ependymoma pilocytic astrocytoma psoriasis astrocytic tumor childhood-onset schizophrenia cryptophthalmia Fraser syndrome congenital anomaly of kidney and urinary tract Fraser syndrome 2 medulloblastoma primitive neuroectodermal tumor amyotrophic lateral sclerosis breast cancer glioblastoma interstitial cystitis malignant ependymoma pilocytic astrocytoma psoriasis astrocytic tumor childhood-onset schizophrenia cryptophthalmia Fraser syndrome 1 head and neck cancer lung adenocarcinoma malignant glioma polydactyly renal agenesis, unilateral atypical teratoid rhabdoid tumor coloboma endometriosis intellectual disability lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.