9JAO | pdb_00009jao

The structure of SMARCAD1 bound to the hexasome in the presence of ADP-BeFx

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], J [auth K]	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1	chromatin binding binding nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity macromolecular conformation isomerase activity protein binding chromatin binding binding nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity macromolecular conformation isomerase activity protein binding ubiquitin binding ubiquitin-like protein binding ATP-dependent chromatin remodeler activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding single-stranded DNA helicase activity 3'-5' DNA helicase activity single-stranded 3'-5' DNA helicase activity nucleosome array spacer activity histone octamer slider activity four-way junction helicase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides double-stranded DNA helicase activity	cellular response to stimulus double-strand break repair response to stimulus DNA double-strand break processing primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA double-strand break processing primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair regulation of DNA recombination regulation of biological process regulation of cellular process DNA recombination biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA metabolic process chromosome separation cell cycle chromosome segregation cell cycle process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle intracellular membraneless organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle intracellular membraneless organelle chromatin chromosome heterochromatin nuclear replication fork nuclear chromosome replication fork site of double-strand break site of DNA damage
B [auth D], D [auth E]	Histone H3	DNA binding binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity structural molecule activity structural constituent of chromatin	-	protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle cellular anatomical structure organelle membraneless organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
C [auth B], E [auth F]	Histone H4	DNA binding binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity structural molecule activity structural constituent of chromatin	protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization	protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle cellular anatomical structure organelle membraneless organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
F [auth G]	Histone H2A	DNA binding binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity structural molecule activity structural constituent of chromatin	regulation of cellular process negative regulation of biological process cellular component organization chromatin organization negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of cellular process negative regulation of biological process cellular component organization chromatin organization negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process	protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle cellular anatomical structure organelle membraneless organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
G [auth H]	Histone H2B 1.1	DNA binding binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity structural molecule activity structural constituent of chromatin	-	protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle cellular anatomical structure organelle membraneless organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
H [auth I]	DNA (157-MER)	-	-	-
I [auth J]	DNA (157-MER)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], J [auth K]	IPR000330	SNF2, N-terminal	Domain
A [auth C], J [auth K]	IPR049730	SNF2/RAD5-like, C-terminal helicase domain	Domain
A [auth C], J [auth K]	IPR038718	SNF2-like, N-terminal domain superfamily	Homologous Superfamily
A [auth C], J [auth K]	IPR003892	Ubiquitin system component CUE	Domain
A [auth C], J [auth K]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth C], J [auth K]	IPR001650	Helicase, C-terminal domain-like	Domain
A [auth C], J [auth K]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
B [auth D], D [auth E]	IPR009072	Histone-fold	Homologous Superfamily
B [auth D], D [auth E]	IPR007125	Histone H2A/H2B/H3	Domain
B [auth D], D [auth E]	IPR000164	Histone H3/CENP-A	Family
C [auth B], E [auth F]	IPR009072	Histone-fold	Homologous Superfamily
C [auth B], E [auth F]	IPR001951	Histone H4	Family
C [auth B], E [auth F]	IPR035425	CENP-T/Histone H4, histone fold	Domain
C [auth B], E [auth F]	IPR019809	Histone H4, conserved site	Conserved Site
C [auth B], E [auth F]	IPR004823	TATA box binding protein associated factor (TAF), histone-like fold domain	Domain
F [auth G]	IPR009072	Histone-fold	Homologous Superfamily
F [auth G]	IPR007125	Histone H2A/H2B/H3	Domain
F [auth G]	IPR002119	Histone H2A	Family
F [auth G]	IPR032454	Histone H2A, C-terminal domain	Domain
F [auth G]	IPR032458	Histone H2A conserved site	Conserved Site
G [auth H]	IPR009072	Histone-fold	Homologous Superfamily
G [auth H]	IPR007125	Histone H2A/H2B/H3	Domain
G [auth H]	IPR055333	Histone H2B, conserved site	Conserved Site
G [auth H]	IPR000558	Histone H2B	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C], J [auth K]	Pharos: Q9H4L7	isolated congenital adermatoglyphia absence of fingerprints-congenital milia syndrome palmoplantar keratosis prostate cancer erythrokeratoderma large cell medulloblastoma primitive neuroectodermal tumor testicular cancer acute myeloid leukemia Fingerprints, Absence of medulloblastoma pancreatic ductal adenocarcinoma testicular germ cell tumor palmoplantar keratoderma-sclerodactyly syndrome Pick disease