9IWM | pdb_00009iwm

X-ray structure of human PPARalpha ligand binding domain-GW7647-TRAP220 coactivator peptide co-crystals obtained by cross-seeding

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00104	Ligand-binding domain of nuclear hormone receptor (Hormone_recep)	Ligand-binding domain of nuclear hormone receptor	This all helical domain is involved in binding the hormone in these receptors.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Peroxisome proliferator-activated receptor alpha	sequence-specific DNA binding DNA binding binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity protein-containing complex binding nuclear receptor activity molecular transducer activity signaling receptor activity ligand-modulated transcription factor activity phosphatase binding protein binding sequence-specific DNA binding DNA binding binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity protein-containing complex binding nuclear receptor activity molecular transducer activity signaling receptor activity ligand-modulated transcription factor activity phosphatase binding protein binding enzyme binding kinase binding mitogen-activated protein kinase kinase kinase binding protein kinase binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity protein domain specific binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding NFAT protein binding MDM2/MDM4 family protein binding nuclear steroid receptor activity ubiquitin-like protein conjugating enzyme binding ubiquitin conjugating enzyme binding transcription coregulator binding transcription coactivator binding lipid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	regulation of biological process regulation of cellular process ketone metabolic process biological regulation metabolic process cellular process regulation of metabolic process regulation of ketone metabolic process developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development regulation of biological process regulation of cellular process ketone metabolic process biological regulation metabolic process cellular process regulation of metabolic process regulation of ketone metabolic process developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development oxoacid metabolic process regulation of lipid metabolic process positive regulation of biological process organic acid metabolic process regulation of primary metabolic process regulation of fatty acid oxidation positive regulation of metabolic process fatty acid oxidation regulation of small molecule metabolic process positive regulation of lipid metabolic process small molecule metabolic process lipid oxidation positive regulation of cellular process positive regulation of fatty acid metabolic process fatty acid metabolic process carboxylic acid metabolic process lipid modification primary metabolic process positive regulation of fatty acid oxidation regulation of fatty acid metabolic process monocarboxylic acid metabolic process positive regulation of small molecule metabolic process lipid metabolic process catabolic process organic acid catabolic process positive regulation of fatty acid beta-oxidation monocarboxylic acid catabolic process positive regulation of lipid catabolic process carboxylic acid catabolic process fatty acid beta-oxidation lipid catabolic process regulation of fatty acid beta-oxidation regulation of catabolic process regulation of lipid catabolic process fatty acid catabolic process positive regulation of catabolic process small molecule catabolic process symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated transformation of host cell biological process involved in interaction with host biological process involved in symbiotic interaction positive regulation of transformation of host cell by virus regulation of transformation of host cell by virus symbiont-mediated perturbation of host process modulation of process of another organism regulation of biological process involved in symbiotic interaction regulation of cell adhesion negative regulation of biological process leukocyte cell-cell adhesion negative regulation of cell adhesion cell adhesion cell-cell adhesion negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of cellular process regulation of cell-cell adhesion ribonucleotide catabolic process pyridine nucleotide catabolic process negative regulation of small molecule metabolic process negative regulation of glycolytic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process negative regulation of ATP metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process negative regulation of nucleotide metabolic process glycolytic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process negative regulation of carbohydrate metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process negative regulation of metabolic process negative regulation of purine nucleotide catabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process negative regulation of nucleotide catabolic process negative regulation of catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process ADP catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process negative regulation of phosphorus metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process negative regulation of hepatocyte apoptotic process regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death epithelial cell apoptotic process negative regulation of apoptotic process regulation of hepatocyte apoptotic process negative regulation of epithelial cell apoptotic process hepatocyte apoptotic process apoptotic process programmed cell death regulation of biosynthetic process rhythmic process circadian regulation of gene expression circadian rhythm regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress response to starvation cellular response to starvation negative regulation of transforming growth factor beta receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus negative regulation of signaling signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction negative regulation of cell communication cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular receptor signaling pathway peroxisome proliferator activated receptor signaling pathway nuclear receptor-mediated signaling pathway monosaccharide metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process gluconeogenesis hexose biosynthetic process glucose metabolic process response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus nucleotide biosynthetic process purine ribonucleotide biosynthetic process positive regulation of phosphate metabolic process purine ribonucleoside triphosphate biosynthetic process positive regulation of nucleotide biosynthetic process regulation of nucleotide biosynthetic process ribonucleotide biosynthetic process purine nucleoside triphosphate biosynthetic process positive regulation of purine nucleotide biosynthetic process ribose phosphate biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of phosphorus metabolic process ribonucleoside triphosphate biosynthetic process positive regulation of ATP metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process purine nucleotide biosynthetic process ATP biosynthetic process positive regulation of nucleotide metabolic process positive regulation of biosynthetic process purine-containing compound biosynthetic process carbohydrate derivative biosynthetic process regulation of purine nucleotide biosynthetic process nucleoside triphosphate biosynthetic process nucleobase-containing compound biosynthetic process positive regulation of purine nucleotide metabolic process positive regulation of ATP biosynthetic process regulation of ATP biosynthetic process RNA metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II nucleic acid metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of glucose metabolic process positive regulation of gluconeogenesis positive regulation of glucose metabolic process regulation of gluconeogenesis positive regulation of carbohydrate metabolic process regulation of carbohydrate biosynthetic process regulation of developmental process cellular developmental process negative regulation of developmental process macrophage derived foam cell differentiation regulation of cell differentiation negative regulation of macrophage derived foam cell differentiation foam cell differentiation cell differentiation regulation of macrophage derived foam cell differentiation negative regulation of cell differentiation regulation of response to nutrient levels negative regulation of response to food negative regulation of response to nutrient levels negative regulation of appetite regulation of response to food response to food response to chemical regulation of biological quality regulation of appetite system process regulation of growth negative regulation of muscle hypertrophy regulation of cardiac muscle tissue growth developmental growth regulation of system process negative regulation of muscle cell differentiation muscle cell differentiation regulation of muscle hypertrophy muscle structure development muscle adaptation negative regulation of growth regulation of organ growth regulation of heart growth cardiac muscle tissue growth muscle tissue development cardiac cell development heart growth negative regulation of striated muscle cell differentiation striated muscle hypertrophy negative regulation of cell growth tissue development negative regulation of developmental growth regulation of muscle cell differentiation striated muscle cell differentiation negative regulation of multicellular organismal process regulation of cellular component organization cardiac muscle cell development cell development negative regulation of cell growth involved in cardiac muscle cell development regulation of striated muscle cell differentiation negative regulation of cardiac muscle tissue growth organ growth cell growth striated muscle tissue development cellular component organization negative regulation of organ growth striated muscle cell development muscle cell development cardiac muscle hypertrophy regulation of multicellular organismal process cellular component organization or biogenesis muscle hypertrophy regulation of muscle adaptation regulation of multicellular organismal development regulation of developmental growth negative regulation of heart growth cardiac muscle tissue development developmental cell growth physiological muscle hypertrophy growth cardiac muscle cell differentiation regulation of cell growth involved in cardiac muscle cell development regulation of muscle system process muscle system process regulation of cell growth regulation of cardiac muscle hypertrophy cardiocyte differentiation cell growth involved in cardiac muscle cell development physiological cardiac muscle hypertrophy negative regulation of cardiac muscle hypertrophy nitric oxide metabolic process reactive nitrogen species metabolic process enamel mineralization tooth mineralization odontogenesis of dentin-containing tooth odontogenesis amelogenesis anatomical structure morphogenesis anatomical structure formation involved in morphogenesis animal organ morphogenesis biomineral tissue development regulation of circadian rhythm cholesterol storage regulation of localization negative regulation of cholesterol storage lipid storage lipid localization negative regulation of lipid localization localization regulation of lipid storage regulation of lipid localization negative regulation of lipid storage macromolecule localization nutrient storage regulation of cholesterol storage hormone-mediated signaling pathway cellular response to chemical stimulus response to hormone cellular response to hormone stimulus reactive oxygen species biosynthetic process reactive oxygen species metabolic process regulation of reactive oxygen species biosynthetic process negative regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species biosynthetic process regulation of reactive oxygen species metabolic process regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response response to external stimulus regulation of inflammatory response negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response epidermis development lipid biosynthetic process positive regulation of lipid biosynthetic process regulation of lipid biosynthetic process response to alcohol response to oxygen-containing compound response to ethanol negative regulation of miRNA transcription miRNA transcription regulation of miRNA metabolic process miRNA metabolic process negative regulation of miRNA metabolic process regulation of miRNA transcription response to peptide hormone response to insulin response to nitrogen compound wound healing response to wounding lipoprotein metabolic process protein metabolic process cellular response to fructose stimulus cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus response to monosaccharide response to carbohydrate cellular response to hexose stimulus cellular response to monosaccharide stimulus response to fructose organic anion transport carboxylic acid transport regulation of transport transport lipid transport regulation of lipid transport regulation of fatty acid transport establishment of localization organic acid transport monocarboxylic acid transport fatty acid transport regulation of organic acid transport behavior adult behavior response to nicotine behavioral response to nicotine response to nutrient circulatory system process regulation of blood pressure negative regulation of blood pressure blood circulation regulation of cytokine production involved in inflammatory response cytokine production regulation of cytokine production negative regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response negative regulation of cytokine production cytokine production involved in inflammatory response negative regulation of gene expression	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B	Mediator of RNA polymerase II transcription subunit 1	protein binding binding signaling receptor binding peroxisome proliferator activated receptor binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity chromatin binding protein binding binding signaling receptor binding peroxisome proliferator activated receptor binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity chromatin binding promoter-specific chromatin binding protein-containing complex binding LBD domain binding protein domain specific binding transcription factor binding general transcription initiation factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear vitamin D receptor binding transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity nuclear thyroid hormone receptor binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription coactivator activity nuclear retinoic acid receptor binding transcription corepressor activity transcription coregulator binding transcription coactivator binding chromatin DNA binding histone acetyltransferase binding enzyme binding nuclear estrogen receptor binding	multicellular organismal process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation negative regulation of cellular process anatomical structure development negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation negative regulation of cellular process anatomical structure development negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation head development central nervous system development animal organ development brain development erythrocyte development homeostatic process hemopoiesis cell development enucleate erythrocyte development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process myeloid cell development homeostasis of number of cells myeloid cell homeostasis enucleate erythrocyte differentiation erythrocyte homeostasis regulation of hormone levels phenol-containing compound metabolic process modified amino acid metabolic process metabolic process regulation of biological quality hormone metabolic process thyroid hormone generation thyroid hormone metabolic process transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly macromolecule metabolic process positive regulation of G0 to G1 transition regulation of cell cycle process positive regulation of biological process G0 to G1 transition positive regulation of cell cycle regulation of G0 to G1 transition positive regulation of cell cycle process cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process sensory organ development eye development visual system development camera-type eye development sensory system development lens development in camera-type eye regulation of biosynthetic process regulation of macromolecule metabolic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process regulation of metabolic process epithelium development retinal pigment epithelium development retina development in camera-type eye tissue development cellular response to stimulus response to lipid response to stimulus response to endogenous stimulus cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical response to steroid hormone cellular response to lipid cellular response to steroid hormone stimulus cellular response to hormone stimulus protein ubiquitination macromolecule modification protein metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport embryonic hindlimb morphogenesis limb development appendage development embryonic limb morphogenesis embryonic morphogenesis hindlimb morphogenesis embryonic appendage morphogenesis embryo development anatomical structure morphogenesis appendage morphogenesis limb morphogenesis embryonic hemopoiesis embryonic organ development regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process cell morphogenesis regulation of cell development positive regulation of developmental process positive regulation of cell differentiation regulation of immune system process regulation of multicellular organismal process regulation of multicellular organismal development regulation of myeloid cell differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis intracellular receptor signaling pathway signaling intracellular signal transduction cell communication peroxisome proliferator activated receptor signaling pathway signal transduction nuclear receptor-mediated signaling pathway fat cell differentiation mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process regulation of body fluid levels secretion mammary gland development gland development body fluid secretion lactation negative regulation of cell population proliferation cell population proliferation regulation of keratinocyte proliferation negative regulation of keratinocyte proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation keratinocyte proliferation response to thyroid hormone cellular response to thyroid hormone stimulus myeloid leukocyte differentiation mononuclear cell differentiation monocyte differentiation leukocyte differentiation branching involved in mammary gland duct morphogenesis development of secondary female sexual characteristics mammary gland morphogenesis reproductive process branching morphogenesis of an epithelial tube mammary gland branching involved in thelarche developmental process involved in reproduction tube morphogenesis gland morphogenesis animal organ morphogenesis thelarche epithelial tube morphogenesis development of secondary sexual characteristics tube development morphogenesis of an epithelium mammary gland duct morphogenesis tissue morphogenesis mammary gland epithelium development morphogenesis of a branching structure morphogenesis of a branching epithelium negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process steroid metabolic process lipid biosynthetic process androgen metabolic process androgen biosynthetic process steroid biosynthetic process hormone biosynthetic process steroid hormone biosynthetic process lipid metabolic process ventricular cardiac muscle tissue morphogenesis heart morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development ventricular trabecula myocardium morphogenesis cardiac chamber development muscle tissue development muscle organ development heart development cardiac chamber morphogenesis cardiac muscle tissue development muscle tissue morphogenesis circulatory system development cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis heart trabecula morphogenesis cardiac ventricle development trabecula morphogenesis muscle organ morphogenesis thyroid hormone receptor signaling pathway hormone-mediated signaling pathway hepaticobiliary system development liver development epidermal cell differentiation epidermis development epithelial cell differentiation skin development keratinocyte differentiation megakaryocyte differentiation megakaryocyte development regulation of vitamin D receptor signaling pathway response to nutrient levels regulation of response to nutrient levels regulation of signal transduction response to vitamin cellular response to vitamin D response to vitamin D regulation of intracellular signal transduction regulation of signaling response to nutrient response to oxygen-containing compound cellular response to oxygen-containing compound vitamin D receptor signaling pathway cellular response to nutrient levels cellular response to vitamin regulation of response to stimulus regulation of cell communication cellular response to nutrient blood vessel morphogenesis angiogenesis vasculature development anatomical structure formation involved in morphogenesis blood vessel development negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death multi-multicellular organism process maternal process involved in female pregnancy mammary gland branching involved in pregnancy female pregnancy multicellular organismal reproductive process multi-organism reproductive process positive regulation of cell communication positive regulation of response to biotic stimulus positive regulation of signal transduction response to type II interferon response to cytokine regulation of type II interferon-mediated signaling pathway response to biotic stimulus cellular response to type II interferon interferon-mediated signaling pathway positive regulation of immune response positive regulation of response to type II interferon cellular response to cytokine stimulus positive regulation of immune system process immune response response to other organism regulation of innate immune response type II interferon-mediated signaling pathway response to external stimulus regulation of response to cytokine stimulus defense response to other organism positive regulation of defense response regulation of immune response regulation of response to type II interferon regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms positive regulation of type II interferon-mediated signaling pathway regulation of response to external stimulus positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway positive regulation of response to stimulus positive regulation of response to external stimulus response to stress regulation of response to stress innate immune response response to external biotic stimulus cell surface receptor signaling pathway positive regulation of innate immune response defense response regulation of cytokine-mediated signaling pathway defense response to symbiont response to peptide positive regulation of cytokine-mediated signaling pathway positive regulation of signaling nuclear receptor-mediated steroid hormone signaling pathway steroid hormone receptor signaling pathway embryonic heart tube development placenta development chordate embryonic development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching regulation of DNA-templated transcription initiation positive regulation of transcription initiation by RNA polymerase II positive regulation of DNA-templated transcription initiation regulation of transcription initiation by RNA polymerase II stem cell differentiation hematopoietic stem cell differentiation hematopoietic progenitor cell differentiation regulation of hepatocyte proliferation positive regulation of cell population proliferation liver morphogenesis positive regulation of epithelial cell proliferation epithelial cell proliferation involved in liver morphogenesis hepatocyte proliferation positive regulation of hepatocyte proliferation branch elongation involved in mammary gland duct branching developmental growth epithelial cell proliferation involved in mammary gland duct elongation axis elongation branch elongation of an epithelium growth developmental growth involved in morphogenesis mammary gland epithelial cell proliferation positive regulation of keratinocyte differentiation regulation of epidermal cell differentiation regulation of epithelial cell differentiation positive regulation of epidermis development positive regulation of epithelial cell differentiation positive regulation of multicellular organismal process regulation of epidermis development regulation of keratinocyte differentiation positive regulation of epidermal cell differentiation animal organ regeneration regeneration transcription elongation by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II positive regulation of DNA-templated transcription, elongation regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II DNA-templated transcription elongation response to hepatocyte growth factor cellular response to growth factor stimulus cellular response to hepatocyte growth factor stimulus response to growth factor cellular response to epidermal growth factor stimulus response to epidermal growth factor positive regulation of intracellular estrogen receptor signaling pathway regulation of intracellular estrogen receptor signaling pathway regulation of intracellular steroid hormone receptor signaling pathway positive regulation of intracellular signal transduction estrogen receptor signaling pathway positive regulation of intracellular steroid hormone receptor signaling pathway	cellular anatomical structure membrane membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle mediator complex membraneless organelle intracellular membraneless organelle chromatin cellular anatomical structure membrane membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle mediator complex membraneless organelle intracellular membraneless organelle chromatin chromosome RNA polymerase II transcription regulator complex core mediator complex transcription regulator complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen nuclear lumen nucleoplasm protein-DNA complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
A	IPR003076	Peroxisome proliferator-activated receptor alpha	Family
A	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A	IPR003074	Peroxisome proliferator-activated receptor	Family
A	IPR050234	Nuclear hormone receptor family NR1 subfamily	Family
A	IPR001723	Nuclear hormone receptor	Family
A	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
A	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily
B	IPR019680	Mediator complex, subunit Med1	Domain
B	IPR051999	Mediator complex subunit 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q07869	myopathy hypertriglyceridemia type 2 diabetes mellitus cancer obesity disorder Crohn disease non-alcoholic fatty liver disease hypertensive disorder Hepatomegaly abdominal obesity-metabolic syndrome acute kidney tubular necrosis proteinuria carcinoma chronic kidney disease hypoglycemia myopathy hypertriglyceridemia type 2 diabetes mellitus cancer obesity disorder Crohn disease non-alcoholic fatty liver disease hypertensive disorder Hepatomegaly abdominal obesity-metabolic syndrome acute kidney tubular necrosis proteinuria carcinoma chronic kidney disease hypoglycemia prostate cancer kidney disease liver cancer sarcomatoid carcinoma experimental autoimmune encephalomyelitis familial hyperlipidemia coronary artery disease hyperlipidemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ileocolitis inherited lipid metabolism disorder alcoholic fatty liver disease invasive ductal breast carcinoma ductal breast carcinoma in situ large cell medulloblastoma liver disease attention deficit hyperactivity disorder, inattentive type schizophrenia benign neoplasm maturity-onset diabetes of the young muscular disease hyperlipoproteinemia pancreatic ductal adenocarcinoma hypoalphalipoproteinemia Pick disease inborn carbohydrate metabolic disorder primitive neuroectodermal tumor drug-induced liver injury ischemia reperfusion injury atherosclerosis liver neoplasm atypical teratoid rhabdoid tumor mammary neoplasms, animal bipolar disorder undifferentiated carcinoma medulloblastoma hyperglycemia osteosarcoma Crohn's colitis pancreatic intraductal papillary-mucinous neoplasm dermatitis, atopic plantar fibromatosis atopic eczema malignant ependymoma autism spectrum disorder breast carcinoma muscle tissue disease fatty liver disease
B	Pharos: Q15648	endometriosis ovarian cancer primitive neuroectodermal tumor astrocytic tumor Chemically-Induced Liver Toxicity drug-induced liver injury glioblastoma hepatocellular carcinoma lung cancer myopathy Pick disease rheumatoid arthritis atypical teratoid rhabdoid tumor large cell medulloblastoma malignant mesothelioma endometriosis ovarian cancer primitive neuroectodermal tumor astrocytic tumor Chemically-Induced Liver Toxicity drug-induced liver injury glioblastoma hepatocellular carcinoma lung cancer myopathy Pick disease rheumatoid arthritis atypical teratoid rhabdoid tumor large cell medulloblastoma malignant mesothelioma osteosarcoma pituitary cancer Sjogren syndrome medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.