9BUB | pdb_00009bub

Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
B [auth R]SCOP2B SuperfamilyG protein-coupled receptor-like 8091120 3000473 SCOP2B (2022-06-29)
E [auth G]SCOP2B SuperfamilyTransducin (heterotrimeric G protein), gamma chain 8070798 3001771 SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth P]PF00214Calcitonin / CGRP / IAPP family (Calc_CGRP_IAPP)Calcitonin / CGRP / IAPP family- Family
B [auth R]PF02793Hormone receptor domain (HRM)Hormone receptor domain- Family
B [auth R]PF000027 transmembrane receptor (Secretin family) (7tm_2)7 transmembrane receptor (Secretin family)This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognise ...This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognised. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97 (Swiss:P48960); calcium-independent receptors for latrotoxin (such as Swiss:O94910), and brain-specific angiogenesis inhibitors (such as Swiss:O14514) amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins (e.g. Swiss:P83119). Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling [1].
Domain
C [auth A]PF00503G-protein alpha subunit (G-alpha)G-protein alpha subunitG proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like ...G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site [3]. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA [3].
Domain
D [auth B]PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth P]Cagrilintide
B [auth R]Calcitonin receptor
C [auth A]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
D [auth B]Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
E [auth G]Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
F [auth N]Nanobody 35---

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth P]IPR018360Calcitonin, conserved siteConserved Site
A [auth P]IPR000443Islet amyloid polypeptideFamily
A [auth P]IPR021117Calcitonin-likeFamily
A [auth P]IPR001693Calcitonin peptide-likeDomain
A [auth P]IPR021116Calcitonin/adrenomedullinFamily
B [auth R]IPR017983GPCR, family 2, secretin-like, conserved siteConserved Site
B [auth R]IPR001688GPCR, family 2, calcitonin receptorFamily
B [auth R]IPR050332G-protein coupled receptor 2Family
B [auth R]IPR036445GPCR family 2, extracellular hormone receptor domain superfamilyHomologous Superfamily
B [auth R]IPR000832GPCR, family 2, secretin-likeFamily
B [auth R]IPR017981GPCR, family 2-like, 7TMDomain
B [auth R]IPR001879GPCR, family 2, extracellular hormone receptor domainDomain
B [auth R]IPR003287GPCR, family 2, calcitonin receptor familyFamily
C [auth A]IPR001019Guanine nucleotide binding protein (G-protein), alpha subunitFamily
C [auth A]IPR011025G protein alpha subunit, helical insertionHomologous Superfamily
C [auth A]IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
C [auth A]IPR000367G-protein alpha subunit, group SFamily
D [auth B]IPR019775WD40 repeat, conserved siteConserved Site
D [auth B]IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
D [auth B]IPR016346Guanine nucleotide-binding protein, beta subunitFamily
D [auth B]IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
D [auth B]IPR001632G-protein, beta subunitDomain
D [auth B]IPR001680WD40 repeatRepeat
D [auth B]IPR020472G-protein beta WD-40 repeatRepeat
E [auth G]IPR015898G-protein gamma-like domainDomain
E [auth G]IPR001770G-protein, gamma subunitFamily
E [auth G]IPR036284G-protein gamma-like domain superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A [auth P]PharosP10997
B [auth R]PharosP30988
C [auth A]PharosP63092
D [auth B]PharosP62873
E [auth G]PharosP59768

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A [auth P]GGL
A [auth P]NH2 RESIDAA0081 , AA0083 , AA0084 , AA0086 , AA0087 , AA0088 , AA0090 , AA0091 , AA0092 , AA0093 , AA0095 , AA0096 , AA0097 , AA0098 , AA0099 , AA0100

PSI-MOD :  L-alanine amide MOD:00090 , L-asparagine amide MOD:00092 , L-aspartic acid 1-amide MOD:00093 , L-glutamine amide MOD:00095 , L-glutamic acid 1-amide MOD:00096 , glycine amide MOD:00097 , L-isoleucine amide MOD:00099 , L-leucine amide MOD:00100 , L-lysine amide MOD:00101 , L-methionine amide MOD:00102 , L-proline amide MOD:00104 , L-serine amide MOD:00105 , L-threonine amide MOD:00106 , L-tryptophan amide MOD:00107 , L-tyrosine amide MOD:00108 , L-valine amide MOD:00109