8ZRY | pdb_00008zry

Structure of human ECHS1 in complex with Crotonoyl-CoA

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Enoyl-CoA hydratase, mitochondrial	isomerase activity intramolecular oxidoreductase activity, transposing C=C bonds intramolecular oxidoreductase activity delta(3)-delta(2)-enoyl-CoA isomerase activity catalytic activity enoyl-CoA hydratase activity hydro-lyase activity lyase activity carbon-oxygen lyase activity crotonyl-CoA hydratase activity 3-hydroxyacyl-CoA dehydratase activity 3-hydroxypropionyl-CoA dehydratase activity	catabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid catabolic process organic acid metabolic process branched-chain amino acid catabolic process carboxylic acid catabolic process metabolic process cellular process small molecule metabolic process branched-chain amino acid metabolic process small molecule catabolic process catabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid catabolic process organic acid metabolic process branched-chain amino acid catabolic process carboxylic acid catabolic process metabolic process cellular process small molecule metabolic process branched-chain amino acid metabolic process small molecule catabolic process amino acid catabolic process fatty acid metabolic process lipid catabolic process lipid modification fatty acid catabolic process monocarboxylic acid catabolic process fatty acid oxidation fatty acid beta-oxidation monocarboxylic acid metabolic process lipid oxidation lipid metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR001753	Enoyl-CoA hydratase/isomerase	Family
A, B, C, D, E A, B, C, D, E, F	IPR029045	ClpP/crotonase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR018376	Enoyl-CoA hydratase/isomerase, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR014748	Enoyl-CoA hydratase, C-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: P30084	Leigh syndrome mitochondrial short-chain Enoyl-Coa hydratase 1 deficiency obesity disorder Alcoholic Intoxication, Chronic hereditary diffuse gastric adenocarcinoma lung cancer ovarian cancer drug-induced liver injury gastric cancer interstitial cystitis neurodegenerative disease pancreatic ductal adenocarcinoma gastric neoplasm tuberculosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.