8ZRN | pdb_00008zrn

Structure of abt

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Neuronal acetylcholine receptor subunit alpha-6	neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity molecular transducer activity signaling receptor activity transmembrane signaling receptor activity acetylcholine receptor activity transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ligand-gated channel activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity molecular transducer activity signaling receptor activity transmembrane signaling receptor activity acetylcholine receptor activity transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ligand-gated channel activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity ligand-gated monoatomic cation channel activity gated channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity monoatomic cation channel activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity monoatomic ion transmembrane transporter activity transmitter-gated channel activity transmembrane transporter activity	trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling biological regulation cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling biological regulation cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication cellular process monoamine transport regulation of localization nitrogen compound transport regulation of catecholamine secretion transport organic hydroxy compound transport dopamine transport localization secretion by cell regulation of secretion by cell catecholamine transport signal release secretion regulation of transport export from cell dopamine secretion establishment of localization regulation of secretion catecholamine secretion amine transport regulation of amine transport regulation of dopamine secretion transmembrane transport monoatomic ion transmembrane transport monoatomic ion transport cellular response to stimulus response to stimulus signal transduction neuromuscular synaptic transmission membrane depolarization regulation of biological quality regulation of membrane potential response to chemical response to nicotine cellular response to nitrogen compound cellular response to acetylcholine response to oxygen-containing compound response to nitrogen compound acetylcholine receptor signaling pathway postsynaptic signal transduction cellular response to oxygen-containing compound cellular response to chemical stimulus response to acetylcholine synaptic transmission, cholinergic	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane presynapse presynaptic membrane dopaminergic synapse cell projection cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane presynapse presynaptic membrane dopaminergic synapse cell projection neuron projection plasma membrane bounded cell projection protein-containing complex plasma membrane protein complex membrane protein complex transporter complex receptor complex acetylcholine-gated channel complex transmembrane transporter complex plasma membrane signaling receptor complex monoatomic ion channel complex
B, D, E	Neuronal acetylcholine receptor subunit beta-4,Soluble cytochrome b562	binding tetrapyrrole binding heme binding electron transfer activity cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding ligand-gated channel activity ligand-gated monoatomic ion channel activity passive transmembrane transporter activity gated channel activity binding tetrapyrrole binding heme binding electron transfer activity cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding ligand-gated channel activity ligand-gated monoatomic ion channel activity passive transmembrane transporter activity gated channel activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity molecular transducer activity signaling receptor activity transmembrane signaling receptor activity acetylcholine receptor activity transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential acetylcholine-gated monoatomic cation-selective channel activity ligand-gated monoatomic cation channel activity excitatory extracellular ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity monoatomic cation channel activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential transmitter-gated channel activity	electron transport chain metabolic process cellular process generation of precursor metabolites and energy behavior multicellular organismal process locomotory behavior positive regulation of cell communication regulation of biological process system process regulation of cellular process nervous system process regulation of system process biological regulation electron transport chain metabolic process cellular process generation of precursor metabolites and energy behavior multicellular organismal process locomotory behavior positive regulation of cell communication regulation of biological process system process regulation of cellular process nervous system process regulation of system process biological regulation positive regulation of biological process positive regulation of transmission of nerve impulse transmission of nerve impulse regulation of nervous system process cell communication regulation of transmission of nerve impulse positive regulation of nervous system process positive regulation of multicellular organismal process regulation of cell communication regulation of multicellular organismal process positive regulation of cellular process localization transport monoatomic ion transport establishment of localization smooth muscle contraction muscle contraction muscle system process transmembrane transport monoatomic ion transmembrane transport regulation of muscle system process regulation of smooth muscle contraction regulation of muscle contraction cellular response to stimulus response to stimulus signaling signal transduction regulation of localization cellular localization modulation of chemical synaptic transmission synaptic signaling regulation of secretion by cell secretion by cell signal release establishment of localization in cell trans-synaptic signaling regulation of signaling neurotransmitter secretion regulation of transport secretion regulation of neurotransmitter transport export from cell cell-cell signaling neurotransmitter transport regulation of secretion chemical synaptic transmission signal release from synapse regulation of trans-synaptic signaling regulation of neurotransmitter secretion anterograde trans-synaptic signaling action potential neuronal action potential regulation of biological quality regulation of membrane potential membrane depolarization adult behavior response to chemical response to nicotine behavioral response to nicotine cellular response to nitrogen compound cellular response to acetylcholine response to oxygen-containing compound response to nitrogen compound acetylcholine receptor signaling pathway postsynaptic signal transduction cellular response to oxygen-containing compound cellular response to chemical stimulus response to acetylcholine synaptic transmission, cholinergic excretion micturition renal system process synaptic transmission involved in micturition neuromuscular synaptic transmission	cellular anatomical structure periplasmic space membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cellular anatomical structure periplasmic space membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule membrane specific granule cell periphery plasma membrane postsynaptic specialization membrane postsynaptic specialization synapse synaptic membrane postsynapse postsynaptic membrane cell junction plasma membrane region cholinergic synapse cell projection neuron projection plasma membrane bounded cell projection protein-containing complex plasma membrane protein complex membrane protein complex transporter complex receptor complex acetylcholine-gated channel complex transmembrane transporter complex plasma membrane signaling receptor complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, C	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
A, C	IPR002394	Nicotinic acetylcholine receptor	Family
A, C	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
A, C	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, C	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
A, C	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
A, C	IPR006201	Neurotransmitter-gated ion-channel	Family
B, D, E	IPR010980	Cytochrome c/b562	Homologous Superfamily
B, D, E	IPR009155	Cytochrome b562	Family
B, D, E	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
B, D, E	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
B, D, E	IPR002394	Nicotinic acetylcholine receptor	Family
B, D, E	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
B, D, E	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
B, D, E	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
B, D, E	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
B, D, E	IPR006201	Neurotransmitter-gated ion-channel	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: Q15825	nicotine dependence substance withdrawal syndrome bipolar disorder Drug Withdrawal Symptoms pellagra depressive disorder psoriasis
B, D, E	Pharos: P30926	nicotine dependence substance withdrawal syndrome visual epilepsy Gustatory seizure lung benign neoplasm abdominal aortic aneurysm anorexia nervosa bipolar disorder cocaine dependence heart disease lung carcinoma myocardial infarction peripheral arterial disease bronchitis small cell lung carcinoma nicotine dependence substance withdrawal syndrome visual epilepsy Gustatory seizure lung benign neoplasm abdominal aortic aneurysm anorexia nervosa bipolar disorder cocaine dependence heart disease lung carcinoma myocardial infarction peripheral arterial disease bronchitis small cell lung carcinoma hypertensive disorder lung adenocarcinoma autism spectrum disorder pulmonary edema chronic obstructive pulmonary disease dental caries squamous cell lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.