8ZA9 | pdb_00008za9

Cryo-EM structure of HBMBPP-BTN2A1-BTN3A1 complex

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], D	Butyrophilin subfamily 3 member A1	protein binding binding signaling receptor binding	cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response biological regulation T cell receptor signaling pathway regulation of response to stimulus immune system process regulation of immune response cellular process antigen receptor-mediated signaling pathway activation of immune response adaptive immune response multicellular organismal process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process regulation of multicellular organismal process positive regulation of cellular process regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process cell population proliferation cell activation lymphocyte activation leukocyte proliferation activated T cell proliferation leukocyte activation mononuclear cell proliferation T cell activation lymphocyte proliferation T cell proliferation regulation of type II interferon production type II interferon production positive regulation of type II interferon production	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane
B [auth E], C [auth G]	Butyrophilin subfamily 2 member A1	protein binding binding signaling receptor binding	cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response biological regulation T cell receptor signaling pathway regulation of response to stimulus immune system process regulation of immune response cellular process antigen receptor-mediated signaling pathway activation of immune response primary metabolic process metabolic process lipid metabolic process regulation of biosynthetic process multicellular organismal process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of cytokine production cytokine production regulation of macromolecule biosynthetic process regulation of multicellular organismal process macromolecule metabolic process regulation of metabolic process	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], D	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth C], D	IPR001870	B30.2/SPRY domain	Domain
A [auth C], D	IPR006574	SPRY-associated	Domain
A [auth C], D	IPR003879	Butyrophylin-like, SPRY domain	Domain
A [auth C], D	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A [auth C], D	IPR053896	Butyrophilin subfamily 3 member A2-like, Ig-C domain	Domain
A [auth C], D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth C], D	IPR013106	Immunoglobulin V-set domain	Domain
A [auth C], D	IPR050504	Immunoglobulin superfamily BTN/MOG domain-containing protein	Family
A [auth C], D	IPR003599	Immunoglobulin domain subtype	Domain
A [auth C], D	IPR043136	B30.2/SPRY domain superfamily	Homologous Superfamily
A [auth C], D	IPR007110	Immunoglobulin-like domain	Domain
A [auth C], D	IPR037954	Butyrophilin subfamily 3, PRY/SPRY domain	Domain
A [auth C], D	IPR003877	SPRY domain	Domain
B [auth E], C [auth G]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B [auth E], C [auth G]	IPR001870	B30.2/SPRY domain	Domain
B [auth E], C [auth G]	IPR006574	SPRY-associated	Domain
B [auth E], C [auth G]	IPR037958	Butyrophilin subfamily 1/2, SPRY/PRY domain	Domain
B [auth E], C [auth G]	IPR003879	Butyrophylin-like, SPRY domain	Domain
B [auth E], C [auth G]	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
B [auth E], C [auth G]	IPR053896	Butyrophilin subfamily 3 member A2-like, Ig-C domain	Domain
B [auth E], C [auth G]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B [auth E], C [auth G]	IPR013106	Immunoglobulin V-set domain	Domain
B [auth E], C [auth G]	IPR050504	Immunoglobulin superfamily BTN/MOG domain-containing protein	Family
B [auth E], C [auth G]	IPR003599	Immunoglobulin domain subtype	Domain
B [auth E], C [auth G]	IPR043136	B30.2/SPRY domain superfamily	Homologous Superfamily
B [auth E], C [auth G]	IPR007110	Immunoglobulin-like domain	Domain
B [auth E], C [auth G]	IPR003877	SPRY domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C], D	Pharos: O00481	lung carcinoma postmenopausal osteoporosis squamous cell lung carcinoma attention deficit hyperactivity disorder, inattentive type bone Paget disease cutaneous lupus erythematosus gastroesophageal reflux disease Hypogonadal Osteoporosis in Males ovarian cancer ulcerative colitis autism spectrum disorder chronic obstructive pulmonary disease dental caries lung cancer osteoporosis lung carcinoma postmenopausal osteoporosis squamous cell lung carcinoma attention deficit hyperactivity disorder, inattentive type bone Paget disease cutaneous lupus erythematosus gastroesophageal reflux disease Hypogonadal Osteoporosis in Males ovarian cancer ulcerative colitis autism spectrum disorder chronic obstructive pulmonary disease dental caries lung cancer osteoporosis pilocytic astrocytoma Sjogren syndrome Crohn disease endogenous depression osteosarcoma
B [auth E], C [auth G]	Pharos: Q7KYR7	autism spectrum disorder endogenous depression juvenile dermatomyositis Sjogren syndrome chronic obstructive pulmonary disease gastroesophageal reflux disease lung carcinoma squamous cell lung carcinoma dermatomyositis glioblastoma ovarian cancer