Annotations: 8Z9L

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], C [auth I], E [auth O], G [auth U]	Angiotensin-converting enzyme	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity peptidyl-dipeptidase activity exopeptidase activity carboxypeptidase activity cation binding ion binding binding metal ion binding small molecule binding	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane extracellular region extracellular space
B [auth F], D [auth L], F [auth R], H [auth X]	Spike protein S1	molecular transducer activity protein binding binding molecular function activator activity signaling receptor binding signaling receptor activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity host cell surface binding host cell surface receptor binding structural constituent of virion structural molecule activity molecular transducer activity protein binding binding molecular function activator activity signaling receptor binding signaling receptor activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity host cell surface binding host cell surface receptor binding structural constituent of virion structural molecule activity identical protein binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction viral gene expression viral translation fusion of virus membrane with host plasma membrane symbiont entry into host cell symbiont entry into host endocytosis involved in viral entry into host cell symbiont-mediated perturbation of host defense response symbiont-mediated perturbation of host process symbiont-mediated-mediated suppression of host tetherin activity modulation of process of another organism regulation of biological process positive regulation of viral life cycle positive regulation of viral process biological regulation positive regulation of biological process modulation by symbiont of entry into host regulation of viral entry into host cell regulation of viral life cycle regulation of viral process positive regulation of viral entry into host cell positive regulation by symbiont of entry into host regulation of biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated perturbation of host immune response symbiont-mediated perturbation of host innate immune response entry receptor-mediated virion attachment to host cell	cellular anatomical structure membrane host extracellular space host cellular component cell periphery plasma membrane host intracellular membrane-bounded organelle host intracellular part host cell membrane host cell cytoplasm part host intracellular organelle host cell endoplasmic reticulum-Golgi intermediate compartment membrane host cell endoplasmic reticulum-Golgi intermediate compartment host cell cytoplasm cellular anatomical structure membrane host extracellular space host cellular component cell periphery plasma membrane host intracellular membrane-bounded organelle host intracellular part host cell membrane host cell cytoplasm part host intracellular organelle host cell endoplasmic reticulum-Golgi intermediate compartment membrane host cell endoplasmic reticulum-Golgi intermediate compartment host cell cytoplasm host cell part host intracellular region host cell plasma membrane virion component virion membrane viral membrane viral envelope host cell surface

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], C [auth I], E [auth O], G [auth U]	IPR031588	Collectrin domain	Domain
A [auth B], C [auth I], E [auth O], G [auth U]	IPR001548	Peptidase M2, peptidyl-dipeptidase A	Family
B [auth F], D [auth L], F [auth R], H [auth X]	IPR044873	Spike glycoprotein S2, coronavirus, heptad repeat 1	Domain
B [auth F], D [auth L], F [auth R], H [auth X]	IPR044366	Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2	Domain
B [auth F], D [auth L], F [auth R], H [auth X]	IPR018548	Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus	Domain
B [auth F], D [auth L], F [auth R], H [auth X]	IPR044341	Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like	Domain
B [auth F], D [auth L], F [auth R], H [auth X]	IPR032500	Spike glycoprotein S1, N-terminal domain, betacoronavirus-like	Domain
B [auth F], D [auth L], F [auth R], H [auth X]	IPR042578	Spike glycoprotein, betacoronavirus	Family
B [auth F], D [auth L], F [auth R], H [auth X]	IPR036326	Spike S1 subunit, receptor binding domain superfamily, betacoronavirus	Homologous Superfamily
B [auth F], D [auth L], F [auth R], H [auth X]	IPR043002	Spike glycoprotein, N-terminal domain superfamily	Homologous Superfamily
B [auth F], D [auth L], F [auth R], H [auth X]	IPR044874	Spike glycoprotein S2, coronavirus, heptad repeat 2	Domain
B [auth F], D [auth L], F [auth R], H [auth X]	IPR043473	Spike glycoprotein S2 superfamily, coronavirus	Homologous Superfamily
B [auth F], D [auth L], F [auth R], H [auth X]	IPR043607	Coronavirus spike glycoprotein S1, C-terminal	Domain
B [auth F], D [auth L], F [auth R], H [auth X]	IPR002552	Spike glycoprotein S2, coronavirus	Domain