3P8C | pdb_00003p8c

Structure and Control of the Actin Regulatory WAVE Complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	Nckap1-like	8045500	4004499	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Cullin repeat-like	8090821	3000059	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FragX_IP	e3p8cA1	A: alpha complex topology	X: Nck-associated protein 1/Cytoplasmic FMR1-interacting protein 1 (From Topology)	H: Nck-associated protein 1/Cytoplasmic FMR1-interacting protein 1 (From Topology)	T: Nck-associated protein 1/Cytoplasmic FMR1-interacting protein 1	F: FragX_IP	ECOD (1.6)
B	Nckap1	e3p8cB1	A: alpha complex topology	X: Nck-associated protein 1/Cytoplasmic FMR1-interacting protein 1 (From Topology)	H: Nck-associated protein 1/Cytoplasmic FMR1-interacting protein 1 (From Topology)	T: Nck-associated protein 1/Cytoplasmic FMR1-interacting protein 1	F: Nckap1	ECOD (1.6)
C [auth D]	KOG1830	e3p8cD1	A: extended segments	X: Wiskott-Aldrich syndrome protein family member 1 (From Topology)	H: Wiskott-Aldrich syndrome protein family member 1 (From Topology)	T: Wiskott-Aldrich syndrome protein family member 1	F: KOG1830	ECOD (1.6)
E [auth F]	KOG2546,ATP-synt_ab_Xtn	e3p8cF1	A: alpha bundles	X: Abl interactor 2 (From Topology)	H: Abl interactor 2 (From Topology)	T: Abl interactor 2	F: KOG2546,ATP-synt_ab_Xtn	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth D]	1.20.5.340	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C [auth D]	6.10.280.150	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D [auth E]	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
E [auth F]	6.10.140.1620	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07159	CYRIA/CYRIB Rac1 binding domain (CYRIA-B_Rac1-bd)	CYRIA/CYRIB Rac1 binding domain	This domain has been annotated as Rac1-binding domain [1, 2]. It can be found in human CYRIA/CYRIB and at the N terminus of CYFIP1/2 [3]. CYFIP proteins are known RAC1 effectors that stimulate actin polymerization [3]. In mice, CYRIB (also known as C ...	This domain has been annotated as Rac1-binding domain [1, 2]. It can be found in human CYRIA/CYRIB and at the N terminus of CYFIP1/2 [3]. CYFIP proteins are known RAC1 effectors that stimulate actin polymerization [3]. In mice, CYRIB (also known as CYRI or FAM49B) negatively regulates RAC1-driven cytoskeletal remodelling and plays a role in restricting infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes [3].	Domain
B	PF09735	Nck-associated protein 1 (Nckap1)	Nck-associated protein 1	-	Family
E [auth F]	PF07815	Abl-interactor HHR (Abi_HHR)	Abl-interactor HHR	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cytoplasmic FMR1-interacting protein 1	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding RNA binding RNA 7-methylguanosine cap binding nucleic acid binding RNA cap binding translation regulator activity small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding RNA binding RNA 7-methylguanosine cap binding nucleic acid binding RNA cap binding translation regulator activity translation repressor activity	multicellular organismal process cellular developmental process developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell growth cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis multicellular organismal process cellular developmental process developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell growth cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis dendrite extension system development developmental process neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth nervous system development developmental growth involved in morphogenesis generation of neurons anatomical structure morphogenesis neuron development cellular process lamellipodium assembly plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly lamellipodium organization cell projection assembly regulation of cellular process modulation of chemical synaptic transmission signaling regulation of translation at synapse, modulating synaptic transmission cell communication regulation of primary metabolic process post-transcriptional regulation of gene expression synaptic signaling postsynaptic modulation of chemical synaptic transmission protein metabolic process regulation of biosynthetic process trans-synaptic signaling regulation of biological process regulation of signaling regulation of protein metabolic process biological regulation cell-cell signaling regulation of translation at postsynapse primary metabolic process regulation of macromolecule metabolic process regulation of translation at synapse gene expression translation macromolecule biosynthetic process chemical synaptic transmission regulation of translation at postsynapse, modulating synaptic transmission regulation of gene expression regulation of trans-synaptic signaling biosynthetic process regulation of translation anterograde trans-synaptic signaling regulation of cell communication regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process axon extension positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size regulation of cell differentiation regulation of neurogenesis regulation of cell development positive regulation of developmental process positive regulation of cell projection organization regulation of biological quality positive regulation of developmental growth regulation of cell projection organization positive regulation of cell development positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization regulation of developmental process positive regulation of biological process regulation of axon extension regulation of nervous system development regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axon extension positive regulation of cellular process positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size regulation of multicellular organismal development regulation of developmental growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation positive regulation of growth regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size system process nervous system process cognition response to electrical stimulus response to stimulus response to abiotic stimulus cellular response to stimulus small GTPase-mediated signal transduction Rac protein signal transduction intracellular signal transduction intracellular signaling cassette signal transduction ruffle organization regulation of cytoskeleton organization regulation of actin filament-based process regulation of protein-containing complex assembly protein-containing complex assembly actin filament-based process regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization regulation of actin filament organization actin cytoskeleton organization actin filament polymerization protein-containing complex organization regulation of actin polymerization or depolymerization actin filament organization regulation of cellular component biogenesis regulation of organelle organization organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization ruffle assembly positive regulation of cellular component biogenesis regulation of cell projection assembly positive regulation of ruffle assembly regulation of plasma membrane bounded cell projection assembly regulation of ruffle assembly positive regulation of plasma membrane bounded cell projection assembly positive regulation of organelle organization regulation of Arp2/3 complex-mediated actin nucleation positive regulation of Arp2/3 complex-mediated actin nucleation regulation of actin nucleation positive regulation of cytoskeleton organization Arp2/3 complex-mediated actin nucleation positive regulation of supramolecular fiber organization positive regulation of actin nucleation actin nucleation regulation of myelination myelination axon ensheathment ensheathment of neurons positive regulation of cell communication cellular response to growth factor stimulus positive regulation of signal transduction regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus neurotrophin signaling pathway positive regulation of neurotrophin TRK receptor signaling pathway enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus neurotrophin TRK receptor signaling pathway regulation of neurotrophin TRK receptor signaling pathway regulation of response to stimulus response to growth factor positive regulation of signaling regulation of cell shape regulation of cell morphogenesis regulation of localization cellular localization transport regulation of transport synaptic vesicle cycle negative regulation of biological process regulation of synaptic vesicle recycling negative regulation of transport establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell negative regulation of synaptic vesicle recycling axon guidance neuron projection guidance dendrite development positive regulation of neuron projection development positive regulation of dendrite development regulation of dendrite development cellular response to nitrogen compound response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to hormone response to chemical response to insulin cellular response to insulin stimulus cellular response to hormone stimulus regulation of modification of postsynaptic actin cytoskeleton regulation of modification of synaptic structure regulation of synapse organization cell junction organization modification of postsynaptic actin cytoskeleton regulation of synapse structure or activity regulation of modification of postsynaptic structure synapse organization modification of synaptic structure modification of postsynaptic structure regulation of lamellipodium assembly regulation of lamellipodium organization positive regulation of lamellipodium assembly positive regulation of lamellipodium organization	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol dendrite terminus axon neuron projection growth cone somatodendritic compartment distal axon dendritic growth cone dendrite dendritic tree site of polarized growth protein-containing complex SCAR complex neuron spine synapse dendritic spine postsynapse cell junction ruffle perinuclear region of cytoplasm cell body neuronal cell body vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen specific granule lumen secretory granule secretory vesicle specific granule anchoring junction focal adhesion cell-substrate junction central region of growth cone axonal growth cone axon terminus presynapse terminal bouton neuron projection terminus filopodium tip actin-based cell projection filopodium tertiary granule lumen tertiary granule peripheral region of growth cone excitatory synapse
B	Nck-associated protein 1	-	cellular component biogenesis cellular component organization cellular component assembly cell projection organization cellular process cellular component organization or biogenesis cell projection assembly positive regulation of organelle organization regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process positive regulation of cellular component organization cellular component biogenesis cellular component organization cellular component assembly cell projection organization cellular process cellular component organization or biogenesis cell projection assembly positive regulation of organelle organization regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process positive regulation of cellular component organization positive regulation of Arp2/3 complex-mediated actin nucleation positive regulation of biological process regulation of actin nucleation actin filament-based process positive regulation of cellular process regulation of biological process regulation of actin filament organization actin cytoskeleton organization positive regulation of cytoskeleton organization actin filament organization biological regulation Arp2/3 complex-mediated actin nucleation positive regulation of supramolecular fiber organization regulation of organelle organization organelle organization positive regulation of actin nucleation regulation of actin cytoskeleton organization regulation of supramolecular fiber organization actin nucleation supramolecular fiber organization cytoskeleton organization cellular response to stimulus small GTPase-mediated signal transduction response to stimulus signaling Rac protein signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development cortical actin cytoskeleton organization cortical cytoskeleton organization anatomical structure morphogenesis cell morphogenesis regulation of cellular component size regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of protein polymerization protein-containing complex assembly regulation of actin filament polymerization regulation of biological quality protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization positive regulation of cellular component biogenesis regulation of actin polymerization or depolymerization regulation of cellular component biogenesis regulation of protein polymerization regulation of actin filament length positive regulation of actin filament polymerization regulation of anatomical structure size apoptotic process cell death programmed cell death cell migration cell motility plasma membrane bounded cell projection assembly regulation of lamellipodium assembly regulation of lamellipodium organization positive regulation of cell projection organization lamellipodium assembly plasma membrane bounded cell projection organization regulation of cell projection organization regulation of cell projection assembly positive regulation of lamellipodium assembly positive regulation of lamellipodium organization regulation of plasma membrane bounded cell projection assembly lamellipodium organization regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly cellular developmental process plasma membrane bounded cell projection morphogenesis cell development neuron projection development neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation generation of neurons neuron development	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium protein-containing complex intracellular anatomical structure SCAR complex cytoplasm extracellular exosome cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium protein-containing complex intracellular anatomical structure SCAR complex cytoplasm extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle ruffle cytosol polymeric cytoskeletal fiber actin filament intracellular membraneless organelle actin cytoskeleton filamentous actin intracellular organelle cytoskeleton membraneless organelle supramolecular fiber supramolecular polymer supramolecular complex plasma membrane membrane leading edge membrane cell periphery plasma membrane region lamellipodium membrane cell projection membrane
C [auth D]	Wiskott-Aldrich syndrome protein family member 1	cytoskeletal protein binding actin binding protein binding binding protein kinase A binding protein kinase A regulatory subunit binding protein-containing complex binding Arp2/3 complex binding	positive regulation of organelle organization regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process positive regulation of cellular component organization positive regulation of Arp2/3 complex-mediated actin nucleation positive regulation of biological process cellular component organization regulation of actin nucleation actin filament-based process cellular component organization or biogenesis positive regulation of cellular process positive regulation of organelle organization regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process positive regulation of cellular component organization positive regulation of Arp2/3 complex-mediated actin nucleation positive regulation of biological process cellular component organization regulation of actin nucleation actin filament-based process cellular component organization or biogenesis positive regulation of cellular process regulation of biological process regulation of actin filament organization actin cytoskeleton organization positive regulation of cytoskeleton organization actin filament organization biological regulation Arp2/3 complex-mediated actin nucleation positive regulation of supramolecular fiber organization regulation of organelle organization organelle organization positive regulation of actin nucleation regulation of actin cytoskeleton organization regulation of supramolecular fiber organization cellular process actin nucleation supramolecular fiber organization cytoskeleton organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly multicellular organismal process cellular developmental process developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell growth cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development dendrite extension system development developmental process neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth nervous system development developmental growth involved in morphogenesis generation of neurons anatomical structure morphogenesis neuron development cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus response to nerve growth factor response to growth factor cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction signaling regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus neurotrophin signaling pathway signal transduction positive regulation of neurotrophin TRK receptor signaling pathway enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cellular response to growth factor stimulus neurotrophin TRK receptor signaling pathway regulation of neurotrophin TRK receptor signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling protein polymerization actin polymerization or depolymerization actin filament polymerization cell junction organization modification of postsynaptic actin cytoskeleton synapse organization modification of postsynaptic structure modification of synaptic structure small GTPase-mediated signal transduction Rac protein signal transduction intracellular signal transduction intracellular signaling cassette lamellipodium organization lamellipodium morphogenesis mitochondrion organization localization import into cell transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol protein-containing complex SCAR complex membrane-bounded organelle mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane postsynapse synapse
D [auth E]	Probable protein BRICK1	protein-containing complex binding binding identical protein binding protein binding	positive regulation of organelle organization regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process positive regulation of cellular component organization positive regulation of Arp2/3 complex-mediated actin nucleation positive regulation of biological process cellular component organization regulation of actin nucleation actin filament-based process cellular component organization or biogenesis positive regulation of cellular process positive regulation of organelle organization regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process positive regulation of cellular component organization positive regulation of Arp2/3 complex-mediated actin nucleation positive regulation of biological process cellular component organization regulation of actin nucleation actin filament-based process cellular component organization or biogenesis positive regulation of cellular process regulation of biological process regulation of actin filament organization actin cytoskeleton organization positive regulation of cytoskeleton organization actin filament organization biological regulation Arp2/3 complex-mediated actin nucleation positive regulation of supramolecular fiber organization regulation of organelle organization organelle organization positive regulation of actin nucleation regulation of actin cytoskeleton organization regulation of supramolecular fiber organization cellular process actin nucleation supramolecular fiber organization cytoskeleton organization cellular response to stimulus small GTPase-mediated signal transduction response to stimulus signaling Rac protein signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction fibroblast proliferation cell population proliferation protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly positive regulation of cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation cell motility cell projection organization plasma membrane bounded cell projection assembly regulation of lamellipodium assembly regulation of lamellipodium organization positive regulation of cell projection organization lamellipodium assembly plasma membrane bounded cell projection organization regulation of cell projection organization regulation of cell projection assembly positive regulation of lamellipodium assembly positive regulation of lamellipodium organization regulation of plasma membrane bounded cell projection assembly lamellipodium organization cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development regulation of cellular component size regulation of biological quality actin polymerization or depolymerization regulation of actin polymerization or depolymerization regulation of actin filament length regulation of anatomical structure size	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium protein-containing complex intracellular anatomical structure SCAR complex cytoplasm intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium protein-containing complex intracellular anatomical structure SCAR complex cytoplasm intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol
E [auth F]	Abl interactor 2	protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity SH3 domain binding protein binding binding protein domain specific binding kinase binding enzyme binding proline-rich region binding cytoskeletal anchor activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding identical protein binding	positive regulation of organelle organization regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process positive regulation of cellular component organization positive regulation of Arp2/3 complex-mediated actin nucleation positive regulation of biological process cellular component organization regulation of actin nucleation actin filament-based process cellular component organization or biogenesis positive regulation of cellular process positive regulation of organelle organization regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process positive regulation of cellular component organization positive regulation of Arp2/3 complex-mediated actin nucleation positive regulation of biological process cellular component organization regulation of actin nucleation actin filament-based process cellular component organization or biogenesis positive regulation of cellular process regulation of biological process regulation of actin filament organization actin cytoskeleton organization positive regulation of cytoskeleton organization actin filament organization biological regulation Arp2/3 complex-mediated actin nucleation positive regulation of supramolecular fiber organization regulation of organelle organization organelle organization positive regulation of actin nucleation regulation of actin cytoskeleton organization regulation of supramolecular fiber organization cellular process actin nucleation supramolecular fiber organization cytoskeleton organization adherens junction organization adherens junction assembly apical junction assembly cellular component biogenesis cell junction organization cellular component assembly cell junction assembly zonula adherens assembly cell-cell junction assembly cell-cell junction organization multicellular organismal process cell projection organization neuron projection development multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development regulation of synapse structure or activity synapse organization regulation of biological quality dendritic spine morphogenesis system development developmental process dendritic spine development postsynapse organization dendritic spine organization regulation of cell projection organization regulation of postsynapse organization nervous system development generation of neurons regulation of neuron projection development cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell morphogenesis neurogenesis dendrite development regulation of anatomical structure morphogenesis plasma membrane bounded cell projection organization dendrite morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis regulation of synapse organization neuron development regulation of dendritic spine morphogenesis neuron projection organization regulation of plasma membrane bounded cell projection organization cell migration cell motility protein phosphorylation phosphorylation primary metabolic process peptidyl-tyrosine modification macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process peptidyl-tyrosine phosphorylation protein modification process phosphorus metabolic process cellular response to stimulus small GTPase-mediated signal transduction response to stimulus signaling Rac protein signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction sensory organ development visual system development epithelial cell differentiation eye morphogenesis lens morphogenesis in camera-type eye animal organ morphogenesis sensory system development camera-type eye morphogenesis lens fiber cell morphogenesis epithelium development eye development animal organ development tissue development lens fiber cell development epithelial cell development sensory organ morphogenesis camera-type eye development lens fiber cell differentiation lens development in camera-type eye neuron migration mitophagy catabolic process macroautophagy autophagy autophagy of mitochondrion process utilizing autophagic mechanism plasma membrane bounded cell projection assembly regulation of lamellipodium assembly regulation of lamellipodium organization positive regulation of cell projection organization lamellipodium assembly positive regulation of cellular component biogenesis regulation of cell projection assembly positive regulation of lamellipodium assembly regulation of cellular component biogenesis positive regulation of lamellipodium organization regulation of plasma membrane bounded cell projection assembly lamellipodium organization cell projection assembly positive regulation of plasma membrane bounded cell projection assembly actin polymerization or depolymerization	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol filopodium tip actin-based cell projection filopodium cell-cell junction adherens junction anchoring junction cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol filopodium tip actin-based cell projection filopodium cell-cell junction adherens junction anchoring junction cell junction protein-containing complex SCAR complex intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle neuron spine synapse neuron projection dendritic spine somatodendritic compartment postsynapse dendrite dendritic tree membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008081	Cytoplasmic FMR1-interacting	Family
A	IPR009828	CYRIA/CYRIB, Rac1 binding domain	Domain
B	IPR019137	Nck-associated protein 1	Family
C [auth D]	IPR003124	WH2 domain	Domain
C [auth D]	IPR028288	SCAR/WAVE family	Family
D [auth E]	IPR033378	Protein BRICK1	Family
E [auth F]	IPR000727	Target SNARE coiled-coil homology domain	Domain
E [auth F]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
E [auth F]	IPR028457	ABI family	Family
E [auth F]	IPR001452	SH3 domain	Domain
E [auth F]	IPR035726	Abl interactor 2, SH3 domain	Domain
E [auth F]	IPR012849	Abl-interactor, homeo-domain homologous domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q7L576	Angelman syndrome dermatomyositis fragile X syndrome lymphoplasmacytic lymphoma ovarian cancer schizophrenia astrocytic tumor Duchenne muscular dystrophy glioblastoma medulloblastoma plasma cell myeloma tuberculosis B-cell chronic lymphocytic leukemia Emery-Dreifuss muscular dystrophy juvenile dermatomyositis Angelman syndrome dermatomyositis fragile X syndrome lymphoplasmacytic lymphoma ovarian cancer schizophrenia astrocytic tumor Duchenne muscular dystrophy glioblastoma medulloblastoma plasma cell myeloma tuberculosis B-cell chronic lymphocytic leukemia Emery-Dreifuss muscular dystrophy juvenile dermatomyositis myopathy psoriasis
B	Pharos: Q9Y2A7	Neurodevelopmental Disorders breast cancer MALT lymphoma intellectual disability lung cancer osteosarcoma
C [auth D]	Pharos: Q92558	primitive neuroectodermal tumor tuberculosis adrenal cortex carcinoma epilepsy intellectual disability lung carcinoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm rheumatoid arthritis astrocytic tumor Epileptic encephalopathy invasive ductal breast carcinoma malignant ependymoma non-small cell lung carcinoma primitive neuroectodermal tumor tuberculosis adrenal cortex carcinoma epilepsy intellectual disability lung carcinoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm rheumatoid arthritis astrocytic tumor Epileptic encephalopathy invasive ductal breast carcinoma malignant ependymoma non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor glioblastoma lung cancer malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma
D [auth E]	Pharos: Q8WUW1	ovarian cancer pancreatic ductal adenocarcinoma
E [auth F]	Pharos: Q9NYB9	acute myeloid leukemia glioblastoma large cell medulloblastoma malignant glioma ovarian cancer psoriasis tuberculosis atypical teratoid rhabdoid tumor hydrolethalus syndrome lung cancer malignant mesothelioma pancreatic intraductal papillary-mucinous neoplasm sinusitis breast cancer juvenile dermatomyositis acute myeloid leukemia glioblastoma large cell medulloblastoma malignant glioma ovarian cancer psoriasis tuberculosis atypical teratoid rhabdoid tumor hydrolethalus syndrome lung cancer malignant mesothelioma pancreatic intraductal papillary-mucinous neoplasm sinusitis breast cancer juvenile dermatomyositis malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia spina bifida

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.