CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

Created:	2006-10-26
Last modified:	2021-03-01

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9 entries where CL6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Systematic Name (OpenEye OEToolkits)	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
Canonical SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI	1.03	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	InChI	1.03	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00257
Name	Clotrimazole
Groups	vet_approved approved
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole Clotrimazolum Clotrimazol 1-(α-(2-Chlorophenyl)benzhydryl)imidazole Clotrimazole 1-(o-Chloro-α,α-diphenylbenzyl)imidazole 1-(o-Chlorotrityl)imidazole
Brand Names	Lucky SuperSoft Athletes Foot Terrasil Rapid-Clear Anti-Fungal Clotrimazole External Cream Terrasil Ringworm Treatment MAX Ringworm Myclo-gyne Cream 1% CVS Pharmacy ITCH RELIEF ANTIFUNGAL Fastrin Anti - Fungal Skin Care Signature Care Athletes Foot Lotrimin Antifungal Fungicure Manicure Pedicure Anti Fungal Quality Choice Athletes Foot Terrasil Foot and Nail Anti-Fungal Maximum Strength Good Sense Athletes Foot antifungal Good Neighbor Pharmacy Clotrimazole Healthy Accents Antifungal Publix athletic foot Canesten External Antifungal Cream Clotrimaderm Vaginal 3 Family Care Clotrimazole Antifungal Meijer Clotrimazole Antifungal Hua Tuo Xian Gao Rite Aid antifungal ringworm Shopko Athletes Foot Terrasil Jock-Itch Treatment MAX Walgreens Clotrimazole 3 Family Care Antifungal Family Wellness Clotrimazole 1 Anti Fungal Cream Kroger ATHLETES FOOT Terrasil Antifungal Cream Maximum Strength Canesten 1% Topical Solution Canesten 1 Vaginal Tablet Combi-pak Gehwol Nail Protection Pen Pedesil Maximum Strength Votriza-AL Fungicure Manicure Pedicure Liquid Gel Exchange Select Atheletes foot First Aid Research Antifungal Cream 1oz Good Neighbor Pharmacy Clotrimazole 3 Fortinia Meijer Athletes Foot Cream AF Skin Repair Canesten Combi 1 Day Terbinafine HCl Chlortimazole and Tolnaftate Leader Clotrimazole Anti-Fungal Our Family Athletes Foot Ciclomazole Canesten V sunmark Clotrimazole 3 Lotrimin CVS Antifungal Ringworm Smart Sense Athletes Foot Antifungal Equaline Clotrimazole Antifungal WinCo Foods Antifungal DermacinRx Therazole Pak Myclo Crm 10mg Clotrimazole Vaginal 3 Clotrimazole Topical Solution USP, 1% Antifungal Cream Shield and Protect Anti-Fungal Terrasil Tinea Treatment Maximum Strength Anti Fungal Canesten Combi 1 Day Internal + External Creams Antifungal Dermatin Antifungal Canesten Extra Strength External Antifungal Cream Clotrimazole Vaginal 6 Clotrimazole 1% Topical Antifungal Cream Fungicure Intensive Myclo Solution CAREALL Clotrimazole Clotrimazole 1% Athletes Foot Anti-Fungal Cream Canesoral Combi Clotrimazol SoundBody Clotrimazole Antifungal Up and Up Athletes Foot CVS Pharmacy Clotrimazole 3 Jock-eze Family Wellness Antifungal First Aid Research Antifungal .5oz Myclo-gyne Inserts Kerasal foot and toe Clotrimazole Extra Strength External Antifungal Cream Myclo Crm 50mg Canesten External Cream Mycozyl AC Canesten Crm 1% Vag Gehwol med Foot Western Family Athletes Foot Family Care Clotrimazole Anti-Fungal Cream 1% Alevazol Terrasil Anti-Fungal Treatment MAX Clotrimaderm Topical Solution 1% USP Clotrimaderm Vaginal 6 Au Kah Chuen Antifungal Clotrimazole/Betameth PerfectHeal Antifungal Antifungal Foot TheraPlus Plus PMS-clotrimazole-betamethasone Desenex Clotrimazole Cream 1% Canesten Crm 1% Top Canesoral Combi 1 Day Canesten 1 Day Internal Cream Canesten Comfortab 1 FungaZoil Advanced TM-Clotrimazole Kroger Jock Itch Canesten Vaginal Inserts 100mg Gyne-Lotrimin 7 Jock Itch Clotrimazole Antifungal Akin Anti-fungal Budpak Antifungal Clotrimazole Dr Sheffield Athletes Foot Silka Ringworm Protective Nail and skin CVSHealth Antifungal Equate Jock Itch Clotrimaderm-fluconazole Combi-pack Lakesia meijer Athletes Foot Foot Care Clotrimazole Topcare Athletes Foot Botanimedix TineaRX Antifungal Drying Emulsion Hua Tuo Xian Gao Antifungal Equaline Antifungal Cream Walgreens Clotrimazole 1MED Clotrimazole 1% Antifungal Cream Canesten 100mg Vaginal Inserts Clotrimazole and Betamethasone Dipropionate Canesten 1% Topical Cream Footlogix Intensive Care Diabetic Formula Rugby Antifungal Clotrimazole Lotrisone Canesten Combi 1 Day Soft Capsule + Extra Strength External Cream Neo-zol Vaginal Cream 2% Quality Choice Clotrimazole Canesten 3 Day Internal Cream Zapotol Clotrimazole ShopRite antifungal Clotrimazol Dual Myclo-derm Solution 1% S-Cream CLOTRIMAZOLE Cream 1% CAREONE Clotrimazole Lotriderm Dynarex Antifungal Up and Up Jock Itch Relief Gyne-Lotrimin 3 Clotrimazole External Antifungal Cream Canesten Combi 3 Day Canesten 3 Vaginal Tablet Combi-pak Gehwol Fusskraft Nail and Skin Protection Clotrimazole Aspiera Anti-Fungal Myclo-derm Cream 1% Canesten 6 Day Internal Cream Neo-zol Vaginal Cream 1% Walgreens Clotrimazole Antifungal Clotrimazole Antifungal Fungicure Manicure Pedicure Gerlasan Hand Clotrimazole-fluconazole Combi TopCare Antifungal Forticept Antifungal Cooling Canesten Soft Capsule 1 MakeSense Olp Clotrimazole Canesten 200 Mg Vaginal Inserts Clotrimazole Jock Itch Walgreens Jock Itch Rugby Clotrimazole Antifungal Cream Canesten Comfortab 3 Aptrimazole 1.0% Antifungal Cream Signature Care Antifungal Athlete Foot Cream with Clotrimazole Smooth Gator Fungus Eliminator ClotrimazOil Antifungal Protective and Moisturizing Skin Extra Strength Clotrimazole Extra Fort -fluconazole Combi Blossom Pharmaceuticals Antifungal Terrasil JockItch Treatment Maximum Strength Micotrin AC Forticept Antifungal Foot Gel Taro-clotrimazole/betamethasone Dipropionate TopCare Clotrimazole 3 Terrasil Foot and Nail Anti-Fungal Sunmark Clotrimazole Terrasil Jock Itch Treatment Maximum Strength Athlete s Foot Afac Terrasil Athletes Foot AntiFungal Treatment Max Fortinia OF Rexall Jock Itch Athletes Foot Atopalm Clotrimazole Antifungal Kleer-Plex Fungistat Fungus Cure Canesten Combi-pak 1 Day Therapy Major Clotrimazole Athletes Foot Antifungal Antifungal Canesten 2% Vaginal Cream Pedesil Footlogix Goodsense Athletes Foot Clotrimaderm Topical Betamethasone Clotrimazole Cura Hongo Antifungal Kleer-Plex Fungistat Athlete Foot Cure Terrasil Tinea Treatment MAX Jock Itch Antifungal WinCo Antifungal Jock Itch Astonea Clotrimazole 1% Athletes Foot Scheinpharm Clotrimazole 1% Myclo Tab 100mg Canesten Combi 1 Day Comfortab + Extra Strength External Cream Soothing Antifungal Cream Clotrimazole Topical Solution 1% Fungicure Pumpspray Fungicure Liquid Gel Oheal Manuka Honey Eczema Cream Rexall Athletes Foot TerrasilMed ANTIFUNGAL UpandUp Clotrimazole Terrasil Anti-fungal Treatment meijer Clotrimazole 3 SIMPLY VITAL Antifungal Cream Thera plus Antifungal Clotrimazole CVS Clotrimazole Maximum Strength Clotrimazole 1% Femmesil Live Better Antifungal Mycelex Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM JiDeSheng Terrasil Anti-Fungal Treatment Best Choice Clotrimazole Leader Athletes Foot Clotrimazole Clotrimazole Topical Occulus Skin Hydrating Topical Foam CLO-1 Clotrimaderm External Cream Oheal Ringworm Cream Forticept Antifungal Foot Cream Canesten Liq 1% Fungistat Max Neo-zol Cream 1% HEB Antifungal Jock Itch Cream with Clotrimazole PRO-EX Anti Fungal Anti-Fungal Signature Care Jock Itch Clotrimazole Athletes Foot
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
C-X-C chemokine receptor type 2	MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYF...	unknown	modulator
Lanosterol 14-alpha demethylase	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682